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irAE
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PISNO for HNSC
Immunotherapy objective response rate (ORR) for HNSC = 0.15
irAE reporting odds ratio (ROR) for HNSC = 1.61
Drug response
Immune checkpoints
Immune infiltration
Data source
CancerRxTissue
VAEN
Or snoRNA
Or Drug
(5Z)-7-Oxozeaenol
5-Fluorouracil
ABT737
ACY-1215
AGI-5198
AGI-6780
AICA Ribonucleotide
AKT inhibitor VIII
AMG-319
ARRY-520
AT-7519
AT13148
AT7867
AZ628
AZ960
AZD4547
AZD5363
AZD5582
AZD6738
AZD7762
Acetalax
Afatinib
Afuresertib
Alisertib
Ara-G
Axitinib
BIBR-1532
BIX02189
BMS-345541
BMS-754807
BPD-00008900
BX-912
BX795
Bicalutamide
Bleomycin (50 uM)
Bosutinib
Brivanib, BMS-540215
Buparlisib
C-75
CD532
CGP-082996
CHIR-99021
CI-1040
CUDC-101
CZC24832
Camptothecin
Carmustine
Cisplatin
Crizotinib
Cyclopamine
Cyclophosphamide
Cytarabine
DMOG
Dabrafenib
Dactinomycin
Daporinad
Dasatinib
Dinaciclib
Docetaxel
EPZ004777
EPZ5676
ETP-45835
Elephantin
Elesclomol
Entinostat
Entospletinib
Epirubicin
Etoposide
FH535
Fedratinib
Flavopiridol
Foretinib
Fulvestrant
GDC0810
GSK1059615
GSK1070916
GSK1904529A
GSK2578215A
GSK2606414
GSK269962A
GSK319347A
GSK343
GSK429286A
GSK690693
Gallibiscoquinazole
Gemcitabine
Genentech Cpd 10
HG6-64-1
I-BET-762
I-BRD9
IC-87114
ICL1100013
IMD-0354
IWP-2
Ibrutinib
Imatinib
Irinotecan
Ispinesib Mesylate
JQ1
JW-7-24-1
KIN001-236
KIN001-260
KIN001-270
KRAS (G12C) Inhibitor-12
LDN-193189
LGK974
LJI308
LY2109761
Lapatinib
Leflunomide
Lenalidomide
Lestaurtinib
Linsitinib
Luminespib
MIM1
MIRA-1
MK-1775
MK-8776
ML323
MPS-1-IN-1
Masitinib
Methotrexate
Midostaurin
Mirin
Mitoxantrone
NPK76-II-72-1
NSC319726
NVP-ADW742
NVP-BHG712
Navitoclax
Nelarabine
Nilotinib
Niraparib
Nutlin-3a (-)
OF-1
OSI-027
OSI-930
OTX015
Obatoclax Mesylate
Olaparib
Osimertinib
Oxaliplatin
P22077
PCI-34051
PD0325901
PD173074
PF-562271
PFI-3
PFI3
PHA-793887
PI-103
PIK-93
PLX-4720
PRIMA-1MET
PRT062607
Paclitaxel
Palbociclib
Panobinostat
Parthenolide
Pelitinib
Pemetrexed
Pevonedistat
Picolinici-acid
Piperlongumine
Podophyllotoxin bromide
Ponatinib
Pyridostatin
QL-VIII-58
QL-X-138
QL-XI-92
QL-XII-47
Quizartinib
RU-SKI 43
RVX-208
Rapamycin
Refametinib
Ruxolitinib
SB216763
SB505124
SB590885
SCH772984
SN-38
SNX-2112
Sabutoclax
Sapitinib
Savolitinib
Selisistat
Selumetinib
Sepantronium bromide
Sinularin
Sorafenib
Sphingosine Kinase 1 Inhibitor II
Sunitinib
T0901317
TAK-715
TGX221
THZ-2-102-1
THZ-2-49
TL-1-85
TL-2-105
TPCA-1
Talazoparib
Tamoxifen
Tanespimycin
Telomerase Inhibitor IX
Temozolomide
Temsirolimus
Teniposide
Tenovin-6
Tivozanib
Topotecan
Torin 2
Trametinib
Tretinoin
Tubastatin A
UMI-77
UNC0638
UNC0642
UNC1215
Ulixertinib
Uprosertib
VE-822
VE821
VNLG/124
VX-11e
VX-702
Venetoclax
Venotoclax
Vinblastine
Vincristine
Vinorelbine
Vismodegib
Vorinostat
WYE-125132
WZ-1-84
WZ3105
WZ4003
Wee1 Inhibitor
Wnt-C59
XMD13-2
XMD14-99
XMD15-27
XMD8-85
Y-39983
YK-4-279
YM201636
ZG-10
Zibotentan
Zoledronate
eEF2K Inhibitor, A-484954
kb NB 142-70
(5Z)-7-Oxozeaenol
5-Fluorouracil
A-443654
A-770041
AICA Ribonucleotide
AKT inhibitor VIII
AR-42
AS601245
AS605240
AT-7519
AZ628
AZD6482
AZD7762
AZD8055
Afatinib
Alectinib
Amuvatinib
Avagacestat
Axitinib
BAY-61-3606
BI-2536
BIX02189
BMS-345541
BMS-509744
BMS-536924
BMS-754807
BX-912
BX795
Belinostat
Bexarotene
Bicalutamide
Bleomycin
Bleomycin (50 uM)
Bortezomib
Bosutinib
Bryostatin 1
CAY10603
CCT-018159
CCT007093
CGP-082996
CGP-60474
CHIR-99021
CI-1040
CMK
CP466722
CP724714
CUDC-101
CX-5461
Cabozantinib
Cetuximab
Cisplatin
Crizotinib
Cyclopamine
Cytarabine
DMOG
Dabrafenib
Dacinostat
Dactolisib
Daporinad
Dasatinib
Docetaxel
Doramapimod
Doxorubicin
EHT-1864
Elesclomol
Embelin
Entinostat
Enzastaurin
Epothilone B
Erlotinib
Etoposide
FH535
FMK
FR-180204
FTI-277
Fedratinib
Foretinib
GNF-2
GSK1070916
GSK1904529A
GSK269962A
GSK319347A
GSK429286A
GSK650394
GSK690693
GW-2580
GW441756
GW843682X
Gefitinib
Gemcitabine
Genentech Cpd 10
HG-5-113-01
HG-5-88-01
HG6-64-1
I-BET-762
ICL1100013
IOX2
IPA-3
Idelalisib
Imatinib
Ispinesib Mesylate
JNK Inhibitor VIII
JNK-9L
JQ1
JQ12
JW-7-24-1
JW-7-52-1
KIN001-236
KIN001-244
KIN001-260
KIN001-266
KIN001-270
KU-55933
LFM-A13
Lapatinib
Lenalidomide
Lestaurtinib
Linifanib
Linsitinib
Luminespib
MG-132
MK-2206
MPS-1-IN-1
Masitinib
Methotrexate
Midostaurin
Mitomycin-C
Motesanib
NG-25
NPK76-II-72-1
NSC-207895
NSC-87877
NU7441
NVP-BHG712
NVP-TAE684
Navitoclax
Nilotinib
Nutlin-3a (-)
OSI-027
OSI-930
OSU-03012
Obatoclax Mesylate
Olaparib
Omipalisib
PAC-1
PD0325901
PD173074
PF-4708671
PF-562271
PFI-1
PFI-3
PHA-665752
PHA-793887
PI-103
PIK-93
PLX-4720
Paclitaxel
Palbociclib
Parthenolide
Pazopanib
Pelitinib
Pevonedistat
Phenformin
Pictilisib
Piperlongumine
Ponatinib
Pyrimethamine
QL-VIII-58
QL-X-138
QL-XI-92
QL-XII-47
QL-XII-61
QS11
Quizartinib
RO-3306
Rapamycin
Refametinib
Rucaparib
Ruxolitinib
S-Trityl-L-cysteine
SB216763
SB505124
SB52334
SB590885
SGC0946
SL0101
SN-38
SNX-2112
STF-62247
Salubrinal
Saracatinib
Seliciclib
Selisistat
Selumetinib
Sepantronium bromide
Serdemetan
Shikonin
Sorafenib
Sunitinib
T0901317
TAK-715
TGX221
THZ-2-102-1
THZ-2-49
TL-1-85
TL-2-105
TPCA-1
TW 37
Talazoparib
Tamoxifen
Tanespimycin
Temozolomide
Temsirolimus
Thapsigargin
Tipifarnib
Tivozanib
Tozasertib
Trametinib
Tretinoin
Tubastatin A
UNC0638
UNC1215
VNLG/124
VX-11e
VX-702
Veliparib
Vinblastine
Vinorelbine
Vismodegib
Vorinostat
WH-4-023
WHI-P97
WZ-1-84
WZ3105
Wee1 Inhibitor
XAV939
XMD11-85h
XMD13-2
XMD14-99
XMD15-27
XMD8-85
XMD8-92
Y-39983
YK-4-279
YM201636
Z-LLNle-CHO
ZG-10
ZM447439
ZSTK474
Zibotentan
rTRAIL
Cutoff (>|Rs|)
0.3
0.4
0.5
0.6
0.7
0.8
0.9
snoRNA
Or Cell type
B cells
B activated
B Immature
B memory
B naive
CD4 activated
CD4 central memory
CD4 effector memory
CD4 memory activated
CD4 memory resting
CD4 naive cells
CD4 naïve
CD4 T cells
CD56bright NK
CD56dim NK cells
CD8 activated
CD8 central memory
CD8 effector memory
CD8 naive cells
CD8 T cells
Central memory T cells
Cytotoxic T cells
Dendritic (DC)
DC immature
DC activated
DC resting
Effector memory T cells
Eosinophil
Exhausted T cells
Gamma delta T cells
Induced Regulatory T cells (iTreg)
Macrophage
Macrophage M0
Macrophage M1
Macrophage M2
MAIT
Mast activated
Mast cells
Mast resting
MDSC
Monocyte
Natural Regulatory T cells (nTreg)
Neutrophil
NK activating
NK cells
NK resting
NK T cells
Plasma cells
Plasmacytoid Dendritic cells (pDC)
T Follicular Help cells (Tfh)
T Regulatory cells (Treg)
Type 2 Helper cells (Th2)
Type 1 Helper cells (Th1)
Type 1 Regulatory T cells (Tr1)
Type 17 Helper cells (Th17)
Cutoff (>|Rs|)
0.3
0.4
0.5
0.6
0.7
0.8
0.9
snoRNA
Or Gene
ADORA2A
ARG1
BTLA
BTN2A1
BTN2A2
BTN3A1
BTN3A2
BTNL3
BTNL9
CCL5
CD160
CD200
CD200R1
CD209
CD226
CD244
CD27
CD274
CD276
CD28
CD40
CD40LG
CD47
CD70
CD80
CD86
CD96
CEACAM1
CTLA4
CX3CL1
CXCL10
CXCL9
EDNRB
ENTPD1
GZMA
HAVCR1
HAVCR2
HLA-A
HLA-B
HLA-C
HLA-DMA
HLA-DMB
HLA-DOA
HLA-DOB
HLA-DPA1
HLA-DPB1
HLA-DQA1
HLA-DQB1
HLA-DRA
HLA-DRB1
HLA-DRB5
HLA-E
HLA-F
HLA-G
HMGB1
ICAM1
ICOS
ICOSLG
IDO1
IFNA1
IFNG
IL10
IL12A
IL12B
IL13
IL1A
IL1B
IL2
IL2RA
IL2RB
IL4
ITGB2
KIR2DL1
KIR2DL3
KIR2DL4
KIR2DS4
KIR3DL1
KIR3DL2
KIR3DL3
LAG3
LAIR1
LGALS3
LGALS9
PDCD1
PDCD1LG2
PRF1
PVR
PVRL2
SELP
SIRPA
SLAMF1
SLAMF7
TDO2
TGFB1
TIGIT
TLR4
TNF
TNFRSF12A
TNFRSF14
TNFRSF18
TNFRSF25
TNFRSF4
TNFRSF9
TNFSF14
TNFSF18
TNFSF4
TNFSF9
VEGFA
VEGFB
VSIR
VTCN1
Cutoff (>|Rs|)
0.3
0.4
0.5
0.6
0.7
0.8
0.9
HNSC
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Cancer Type
snoRNA
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