tRic
The TRIC refers to "tRNA in cancers". Transfer RNAs (tRNAs) play essential roles in tumorigenesis. The database tRNA in Cancer (TRIC) show the dynamic landscape of tRNAs expression across 31 cancer types and more than 10000 samples from The Cancer Genome Atlas (TCGA). Here we systematically analyzed tRNA expression profiles at gene, codon and amino acid levels and the functional consequence (e.g. patient tumor stage, subtype, and survival). We also try to connect the differentially expression of tRNA and the translational control in tumor.
Users Can:
- Search tRNA expression profile in different cancer types.
- Analyze the expression alteration of tRNAs between tumor and normal samples.
- Analyze the tRNA related clinically relevant events.
- Comparative analyze the expression and expression alteration at tRNA, codon and amino acid levels.
- Analyze codon usage among whole genome.
- Download all expression data to independently validate a pattern of interest.
Where to Cite:
tRic has been published at:
Zhang, Z., Ruan, H., Liu CJ. et al. tRic: a user-friendly data portal to explore the expression landscape of tRNAs in human cancers. RNA Biology (2019) doi: 10.1038/s42003-018-0239-8
Please also cite:
Zhang, Z., Ye, Y., Gong, J. et al. Global analysis of tRNA and translation factor expression reveals a dynamic landscape of translational regulation in human cancers. Commun Biol 1, 234 (2018) doi: 10.1080/15476286.2019.1657744
tRNA Level
Codon Level
AA Level
Code Usage
Subtype
